Alexander Ervik Johnsen, Citrix Technology Professional has put together a good set of recommendations for  configuring anti-virus services with Citrix XenApp and Citrix EdgeSight installations.

Ervik's makes a number of sound suggestions to help ease the negative affect that standard Anti-virus settings can cause on Citrix XenApp servers - as he says,  these servers are not used in the normal sense of the word Server, the scan and realtime aggressiveness needs to be adjusted for the Antivirus Software or performance will be affected.

His recommendations for XenApp include:

• Change what gets scanned to scan inbound only. Typical settings are to scan on write, read access, etc.
• Scan local drives only
• Exclude the pagefile from being scanned.
• Exclude .dat and .tmp files.